PAX6 maintains β cell identity by repressing genes of alternative islet cell types

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PAX6 maintains β cell identity by repressing genes of alternative islet cell types.

Type 2 diabetes is thought to involve a compromised β cell differentiation state, but the mechanisms underlying this dysfunction remain unclear. Here, we report a key role for the TF PAX6 in the maintenance of adult β cell identity and function. PAX6 was downregulated in β cells of diabetic db/db mice and in WT mice treated with an insulin receptor antagonist, revealing metabolic control of exp...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 2016

ISSN: 0021-9738,1558-8238

DOI: 10.1172/jci88015